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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
18.48
Human Site:
S546
Identified Species:
33.89
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
S546
S
V
A
S
A
V
P
S
A
R
P
R
H
Q
K
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
A547
V
A
S
A
V
P
S
A
R
P
R
H
Q
K
S
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
K531
A
R
P
R
Q
H
Q
K
S
M
S
A
S
V
H
Dog
Lupus familis
XP_536123
782
87409
S533
A
V
A
S
A
V
P
S
A
R
P
R
H
Q
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
S546
T
V
A
S
A
G
P
S
A
R
P
R
H
Q
K
Rat
Rattus norvegicus
O08678
793
88216
S546
T
V
A
S
A
G
P
S
A
R
P
R
H
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
S544
A
V
A
S
A
I
P
S
T
R
P
R
H
Q
K
Chicken
Gallus gallus
Q9IA88
798
88848
L520
S
N
D
S
S
V
A
L
S
S
C
L
A
G
Q
Frog
Xenopus laevis
NP_001085126
792
88624
R546
A
V
P
S
A
R
P
R
H
Q
K
S
M
S
A
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
A674
I
L
H
Q
Q
I
Q
A
L
S
L
G
H
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
F943
Q
L
T
H
N
A
S
F
S
V
T
P
S
S
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
T274
R
Q
H
R
W
F
Q
T
H
L
P
R
Y
L
A
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
D395
E
N
K
S
L
I
K
D
M
K
A
N
K
S
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
0
0
93.3
N.A.
86.6
86.6
N.A.
80
20
26.6
6.6
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
26.6
13.3
100
N.A.
93.3
93.3
N.A.
93.3
40
40
33.3
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
8
39
8
47
8
8
16
31
0
8
8
8
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
16
0
0
0
0
0
8
0
16
0
% G
% His:
0
0
16
8
0
8
0
0
16
0
0
8
47
0
8
% H
% Ile:
8
0
0
0
0
24
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
0
0
8
8
0
8
8
0
8
8
39
% K
% Leu:
0
16
0
0
8
0
0
8
8
8
8
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
8
8
0
0
8
0
0
% M
% Asn:
0
16
0
0
8
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
16
0
0
8
47
0
0
8
47
8
0
0
0
% P
% Gln:
8
8
0
8
16
0
24
0
0
8
0
0
8
39
8
% Q
% Arg:
8
8
0
16
0
8
0
8
8
39
8
47
0
0
0
% R
% Ser:
16
0
8
62
8
0
16
39
24
16
8
8
16
24
8
% S
% Thr:
16
0
8
0
0
0
0
8
8
0
8
0
0
0
0
% T
% Val:
8
47
0
0
8
24
0
0
0
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _